Blood Transfusion - 4 2019 (July-August)
Diversity in a blood bag: application of omics technologies to inform precision transfusion medicine
Authors:  Tamir Kanias, Michael P. Busch
Pages:  258-262
To cite this article:  Blood Transfus 2019; 17: 258-62 DOI 10.2450/2019.0056-19
Doi:  10.2450/2019.0056-19
Published online:  05/06/2019

In recent years, red blood cells (RBCs) have finally received well-deserved attention from scientists in the field of transfusion medicine. These biconcave-shaped oxygen-carrying cells were often ignored by cell biologists for being "too simple", due to their lack of intracellular organelles and DNA, and for being relatively unresponsive to their external environment. They were often regarded as an annoying source of contamination from haemoglobin when processing tissues or isolating white blood cells. Special attention was given to studies of RBC response to cold storage and cryopreservation, which gave rise to the widely used, and perhaps obsolete, term of "the RBC storage lesion"1.  [ … ]
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