Severe thrombocytopenia in two children following split liver transplantation from the same donor with idiopathic thrombocytopenia

Abstract

Introduction
Immune-mediated disorders can be transferred to recipients during solid organ transplantation by residual leukocytes from the donor organ. The most common form is passenger lymphocyte syndrome which provokes hemolytic anemia due to anti-A or anti-B produced by the lymphocytes present in the transplanted organ, in the case of ABO incompatibility between the recipient and donor. Transplantation-mediated alloimmune thrombocytopenia (TMAT) is an uncommon form of donor-derived thrombocytopenia following solid organ transplantation. Rarely described, this condition occurs following transplantation from a donor with immune thrombocytopenia (ITP) and may lead to hemorrhagic complications, graft failure, and even death^1-3. In this case report, we describe two children who developed severe, life-threatening thrombocytopenia after in situ split liver transplantation from the same donor. [ … ]