Haemophilia A/B carriers: haemorrhagic burden of disease and open issues

Abstract

Preview
The severity and burden of symptomatic spontaneous bleeding in women with haemophilia (WwH) remains unclear. The guidelines for the management of haemophilia1 state that most WwH are asymptomatic, but a review of literature shows that many bleeds also occur in women (Table I). So how should they be effectively monitored2? Management of bleeding should be very similar to that performed in male haemophiliacs3. Joint bleeding was proven to have a strong and negative impact on the quality of life of these women4. Prevention procedures should be put in place to avoid haemophiliac arthropathy as far as possible. Intracranial haemorrhage (ICH) is the most serious event in haemophilia. [ … ]