"The times they are a-changin", ... or maybe not?

Abstract

Preview
The current treatment of haemophilia is based on replacement of the missing coagulation factor and this can be done when the bleeding actually occurs (on-demand therapy) or as part of a preventive approach (prophylaxis)1,2. Nowadays, prophylaxis of bleeding, involving the regular infusion of the deficient coagulation factor, represents the mainstay of haemophilia care. Indeed, its early implementation reduces the risk of joint bleeding and the resulting development of arthropathy, allowing patients to lead a life comparable to that of non-affected individuals. […]