COVID-19 vaccination, anticoagulation level and warfarin treatment

Abstract

Dear Sir,
We would like to share ideas on the publication “Anti-SARS-CoV-2 vaccination does not influence anticoagulation levels in stable long-term warfarin treatment”¹. Lotti et al. concluded that “No influence on the quality of OAT was detected … thus confirming the stability of anticoagulation levels”¹. We agree that the interaction between COVID-19 and warfarin is an interesting issue. Conceptually, if there is a linked biomechanism, there should be an interaction. Based on available evidence, there is no biological process of the immunogenesis by COVID-19 that is linked to the pharmacological action of warfarin.