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PLASTIC RECONSTRUCTIVE AND REGENERATIVE SURGERY

Letter to the Editor

Vol. 21 No. 4 (2023): Blood Transfusion 4-2023 (July-August)

A novel serological RhD confirmatory test for patients with warm autoimmune haemolytic anaemia with a strong positive direct antiglobulin test

Authors

Chunchen Yang , Jiewei Zheng , Ruiming Rong , Dong Xiang

Key words: serological RhD test, warm autoimmune hemolytic anemia, antiglobulin test
DOI: 10.2450/2022.0071-22
Immunohematology
Publication Date: 2022-06-07

Abstract

Dear Sir,
Warm autoimmune haemolytic anaemia (WAIHA) is the most common type of AIHA (65-70%) and is mostly associated with the presence of immunoglobulin (Ig) G on red blood cells (RBCs)1. Individuals with WAIHA typically present with symptoms of anaemia, and some severe cases require chronic blood transfusion. However, in AIHA, precise serological phenotyping is not always possible since antihuman-globulin (AHG)-reacting antisera are not suitable for patients with a positive direct antiglobulin test (DAT)1.

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Authors

Chunchen Yang - Department of Transfusion, Zhongshan Hospital, Fudan University, Shanghai, China

Jiewei Zheng - Immunohematology Reference laboratory, Shanghai Blood Center, Shanghai, China

Ruiming Rong - Department of Transfusion, Zhongshan Hospital, Fudan University, Shanghai, China

Dong Xiang - Immunohematology Reference laboratory, Shanghai Blood Center, Shanghai, China

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