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PLASTIC RECONSTRUCTIVE AND REGENERATIVE SURGERY

Review

Ahead-of-Print

A "movement" worth making: why and how Transfusion Services can play a role in Fecal Microbiota Transplant programs

Authors

Daniele Prati , Flavio Caprioli , Luisa Stea , Alessandra Berzuini , Denise Pizzotti , Errica Petrillo , Elena Coluccio , Elisa Erba , Giuseppe Lamorte , Francesca Ferrari , Lisa Cariani , Chiara Amoroso , Anna C. Preti , Alessandra Bandera , Annapaola Callegaro , Silvana Castaldi , Massimo Cardillo , Maurizio Vecchi , Luca Valenti , Vincenzo De Angelis

Key words: fecal microbiota transplantation (FMT), transfusion services, innovative therapies, substances of human origin
DOI: 10.2450/BloodTransfus.929
Therapies based on substances of human origin (SoHO)
Publication Date: 2025-03-12

Abstract

Fecal Microbiota Transplantation (FMT) is an innovative therapy with growing applications, particularly for recurrent Clostridioides difficile infections (rCDI). However, the broader use of FMT is challenged by the complexities of donor recruitment, the necessity of stringent screening protocols, and the need for maintaining high-quality stool biobanks. This paper explores the integration of FMT programs within transfusion medicine departments, taking advantage of their expertise in donor management and biological material processing. Despite the complexities of donor screening, including a low eligibility rate, the collaboration between transfusion services and other hospital departments demonstrates a viable model for expanding FMT access. Additionally, the recent EU regulations on substances of human origin (SoHO) offer a framework for standardizing and scaling stool banking, enhancing the safety and efficacy of FMT procedures.

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Authors

Daniele Prati - Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; National Blood Centre, Italian National Institute of Health, Rome, Italy https://orcid.org/0000-0002-2281-7498

Flavio Caprioli - Gastroenterology and Endoscopy Unit, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy https://orcid.org/0000-0002-8077-8175

Luisa Stea - Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy https://orcid.org/0009-0005-2102-5308

Alessandra Berzuini - Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy https://orcid.org/0000-0003-1224-8970

Denise Pizzotti - Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

Errica Petrillo - Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

Elena Coluccio - Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

Elisa Erba - Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Healthcare Professions, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy

Giuseppe Lamorte - Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

Francesca Ferrari - Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

Lisa Cariani - Microbiology and Virology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

Chiara Amoroso - Gastroenterology and Endoscopy Unit, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy https://orcid.org/0000-0001-6566-9512

Anna C. Preti - Quality Units, Fondazione Ca' Granda Policlinico di Milano, Milan, Italy

Alessandra Bandera - Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy; Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

Annapaola Callegaro - Microbiology and Virology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

Silvana Castaldi - Quality Units, Fondazione Ca' Granda Policlinico di Milano, Milan, Italy; Department of Biomedical Sciences for Health, University of Milan, Milan, Italy https://orcid.org/0000-0003-1716-6624

Massimo Cardillo - Unità Trapianti Lombardia - NITp Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Milan, Italy

Maurizio Vecchi - Gastroenterology and Endoscopy Unit, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy

Luca Valenti - Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy

Vincenzo De Angelis - National Blood Centre, Italian National Institute of Health, Rome, Italy https://orcid.org/0000-0002-8557-1798

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