Abstract
In this report we present a series of African-origin pregnant women with anti-CD36 isoantibodies. A case of Fetal/Neonatal Alloimmune Thrombocytopenia due to strong anti-CD36 isoantibodies, identified in 2020 in our reference laboratory, led us to hypothesize the potential implication of these antibodies in causing the weak red cell agglutination observed in the indirect antiglobulin test. Since January 2021, we have implemented the screening for CD36 antibodies for selected samples with a weak RBC pan-agglutination pattern and a suspected high-incidence specificity. In the past 3 years, we have detected anti-CD36 antibodies in seven pregnant women. In this report we describe the serological findings observed in these samples, present the clinical cases and discuss the recommendations for the management of these patients.
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